Cover Nature Methods fULM

Cover and video animation for Nature Methods journal

This cover was created to go with the paper "Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale" from Physics for medicine research laboratory. Ultrasound localization microscopy (ULM) has achieved transcranial imaging of cerebrovascular flow, up to micrometre scales, by localizing intravenously injected microbubbles; however, the long acquisition time required to detect microbubbles within microscopic vessels has so far restricted ULM application mainly to microvasculature structural imaging. The present paper shows how ULM can be modified to quantify functional hyperemia dynamically during brain activation reaching a 6.5-µm spatial and 1-s temporal resolution in deep regions of the rat brain.